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The first and rate-limiting step involves generating the dipeptide -glutamylcysteine (-EC) from glutamate and cysteine, catalyzed by glutamate cysteine ligase (GCL)

The alcohol is a bacteriostatic agent, meaning it prevents bacteria from reproducing

Patients with pancreatic cancer have higher levels of serum fructose which induces TKT expression to drive nucleic acid synthesis in cancer cells (104)